MMP1, matrix metallopeptidase 1, 4312

N. diseases: 589; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0079474
Disease: Hallopeau-Siemens Disease
Hallopeau-Siemens Disease 		0.630 Biomarker disease GENOMICS_ENGLAND
CUI: C0079474
Disease: Hallopeau-Siemens Disease
Hallopeau-Siemens Disease 		0.630 Biomarker disease GENOMICS_ENGLAND
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 Biomarker disease RGD The MMP-1 mRNA expression level was obviously higher in the COPD of CDS group than in the COPD model group (P < 0.01). 23173262 2012
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Biomarker disease RGD ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. 11179039 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Biomarker disease RGD Regulation of collagen degradation in the rat myocardium after infarction. 8531210 1995
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.250 Biomarker disease RGD Ilomastat improves TNB-induced UC in rats by inhibiting the MMP-1 activity. 18837084 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.240 Biomarker disease RGD Effect of hyperglycemia on apoptosis of notochordal cells and intervertebral disc degeneration in diabetic rats. 19951028 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.240 Biomarker disease RGD [Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats]. 21866669 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.240 Biomarker disease RGD [Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats]. 21866669 2011
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.230 ModifyingMutation disease RGD Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis. 14606082 2003
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.230 Biomarker disease RGD Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats. 16124044 2005
CUI: C0243026
Disease: Sepsis
Sepsis 		0.230 Biomarker disease RGD Expression of metalloproteinases and interleukins on anastomoses in septic rats. 23478082 2013
CUI: C0409959
Disease: Osteoarthritis, Knee
Osteoarthritis, Knee 		0.230 Therapeutic disease RGD Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. 21167838 2011
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.220 Biomarker disease RGD The protective effect of BHR on renal function in rats with GS is possibly by way of influencing expressions of TGF-beta1, TIMP-1 and MMP1 to regulate the state of extracellular matrix and lessen the matrix aggregation. 21275176 2010
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.220 Biomarker disease RGD NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. 20406136 2010
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.220 Biomarker disease RGD Total glucosides of Danggui Buxue Tang attenuates bleomycin-induced pulmonary fibrosis via inhibition of extracellular matrix remodelling. 22571259 2012
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Periodontal ligament remodeling and alveolar bone resorption during orthodontic tooth movement in rats with diabetes. 20082587 2010
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.200 Biomarker phenotype RGD In the present study, we performed immunohistochemistry, RT-PCR, and Western blot to examine the dynamic expression of TGF-β1, TGF-β1 receptor type I (TGF-β RI), matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) during intimal hyperplasia in grafted veins of a rat model generated by grafting a portion of the right internal jugular vein to the ipisiliary carotid artery. 22860019 2012
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.200 Biomarker phenotype RGD Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats. 23087098 2012
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Biomarker phenotype RGD [Precondition with doxycycline administration abates ischemia/reperfusion injury and reduces the expression of matrix metalloproteinase-1/9 in myocardium in rat in vivo]. 17996137 2007
CUI: C0036439
Disease: Scoliosis, unspecified
Scoliosis, unspecified 		0.200 Biomarker disease RGD Expression of matrix metalloproteinase-1 (MMP-1) in Wistar rat's intervertebral disc after experimentally induced scoliotic deformity. 21554726 2011
CUI: C0039503
Disease: Tendinitis
Tendinitis 		0.200 Biomarker disease RGD Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases. 22926534 2013
CUI: C0178664
Disease: Glomerulosclerosis (disorder)
Glomerulosclerosis (disorder) 		0.200 Biomarker disease RGD NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. 20406136 2010